Smaller, faster, better: the three revolutions in drug making.
by William Wells
Testing one drug at a time in a mouse is just not going to cut it in today's
pharmaceutical industry. In the last ten years there have been three overlapping
revolutions in biology, chemistry and robotics, which together have changed
the nature of drug hunting.
Large-scale sequencing of DNA has created the field of genomics.
By comparing genes to one another biologists can take a quick guess at what
the corresponding protein does, and what disease it might be involved in.
Suddenly there are tens or hundreds of proteins that, if they can be turned
off with a drug, might be the key to stopping cancer.
What will turn the proteins off is a chemical, and there are more of them
too. Combinatorial chemistry is a way of making millions of
chemicals where once there were handfuls. Everything is reacted with everything
in complicated matrices, giving perhaps a million (100x100x100) chemicals
from only three hundred (100+100+100) starting materials.
If more chemicals have to be tested against more proteins, the testers better
get faster. Drug testing has been roboticized and miniaturized. A drug can be tested in a single cell, a tiny capillary tube, or even a drop that holds a few worms.
Access Excellencewill explore these revolutions in detail over the next few months. What follows is the first two installments of this exploration: