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The Life Cycle Of Bacteriophage Lambda

   Copyright 2004 by Alberts, Bray, Johnson, Lewis, Raff, Roberts, Walter.
Garland Publishing: Taylor Francis Group.

The linear double-stranded DNA lambda genome contains about 50,000 nucleotide pairs and encodes 50-60 different proteins. When the lambda DNA enters the cell the ends join to form a circular DNA molecule. The bacteriophage can multiply in E. coli by a lytic pathway, which destroys the cell, or it can enter a latent prophage state. Damage to a cell carrying a lambda prophage induces the prophage to exit from the host chromosome and shift to lytic growth (green arrows). The entrance and exit of the lambda DNA from the bacterial chromosome are site-specific recombination events.  Fair Use and Copyright info

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